Engineered Phage with Aggregation‐Induced Emission Photosensitizer in Cocktail Therapy against Sepsis (Adv. Mater. 6/2023)

Abstract

Sepsis Therapy In article number 2208578, Ming-Yu Wu, Luojia Chen, Lianrong Wang, Shi Chen, Meijia Gu, and co-workers develop a novel strategy combining an AIE photosensitizer with a phage that not only selectively identifies bacterial species but also shows a powerful ability to kill pathogenic bacteria in sepsis diagnosis and treatment. This synergetic therapy strategy combining phage cocktail therapy and photodynamic therapy offers a strong “1 + 1 > 2” bactericidal efficacy in vitro and in vivo.