Engineered olfactory system for in vitro artificial nose

Abstract

• Artificial nose drew generous attention in the field of bionic organs • Construction with sensing module, recognition system and functional structure are introduced • Recognition technology, substrate materials and microarray integration in artificial nose are prospected The engineered biomimetic sensors can not only realize the action of organs, but also combine functional materials as in vitro organs by simulating the response of biological organs to different environmental signals. Artificial nose is a concept proposed by imitating biological olfactory system, simulating olfactory nerve cells, olfactory bulb and olfactory cortex through different materials to realize olfactory function. The sensor array used to sense external gas stimulation can be analyzed based on different recognition principles through different original signals such as optics, electricity, electrochemistry and bioelectricity. Furthermore, combined with pattern recognition and microarray technology, artificial nose can be highly integrated with biocompatible and other important properties to achieve in vitro application. The design principle and necessary components of artificial nose are introduced in this paper including sensing structure, recognition system and functional module. At the same time, the potential development prospects of molecular recognition technology, polymer-based materials and microarray integration in artificial nose are prospected.