Abstract
Antibodies Antibody-binding receptors, including Fc receptors and complement receptors, play a central role in mediating antibody-dependent immune activation. Fox et al. examined the role of Fcγ receptors and complement component 1q (C1q) in meditating the therapeutic effects of monoclonal immunoglobulin G antibodies targeting Chikungunya virus. They used antibody engineering in conjunction with mouse strains lacking C1q or Fcγ receptors to show that the therapeutic effects of these antibodie s are dependent on expression of Fcγ receptors. Furthermore, depleting distinct immune cell types revealed that engagement of Fc receptors on monocytes is central in driving antibody-dependent viral clearance. Sci. Immunol. 4 , eaav5062 (2019).
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