Abstract
ABSTRACT Acute diarrhea diseases associated to Rotavirus In the period of 2001-2002, a total of 1163 fecal samples were collected from children less than five years ofage with diarrhea, at the Hospital Albina Patino and other health centers in Cochabamba city. Rotavirusinfection general prevalence was 19% (220), distributed among hospitalized children 24% (77) andoutpatients 17% (143). Rotavirus infections were observed along the whole study period, with highestprevalence in coldest months: April (24%), May (34%) and June (28%) and lowest frequencies (8-15%) inFebruary, August, and September. Major rotavirus outbreak was significantly associated with the driestand colder season. The highest percentage of rotavirus infections (36,3%) was found among childrenbetween 7-12 months of age. Moderate dehydration, vomits and fever were the clinical symptoms morefrequently associated with rotavirus acute gastroenteritis, being dehydration more common in hospitalizedpatients. The distribution of P and G genotypes analyzed by RT-PCR was: G1 (44%), G2 (6%), P[8] (24%)and P4 (15%). A co-infection P[8]P[6] was observed in 3 samples (4%). Genotype P[6] was foundassociated to outpatients. These findings, highlight that rotavirus is an important cause of acutegastroenteritis and that any of the currently available vaccines would potentially be protective againstcirculating strains found in the city of Cochabamba.(
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