Abstract
Etiology of chronic inflammatory bowel disease (CIBD) likely involves immunological factors acting on digestive tract. Its incidence and prevalence are growing. CIBD includes ulcerative colitis and Crohn's disease. Diagnosis relies on clinical and imaging data, highlighting endoscopy (colonoscopy with ileoscopy) and magnetic resonance enterography (differential diagnosis of Crohn's disease), and on anatomopathological findings. Drugs widely use in ulcerative colitis are oral and topical (intrarectal) aminosalicylates. In mild and severe outbreaks, corticosteroids continue being the treatment of choice. Immunomodulatory drugs (azathioprine and 6-mercaptopurine and cyclosporine), granulocytapheresis and biological drugs, such as anti-TNF, can be used in patients with refractory cases. Recently, new drugs have been included: vedolizumab (anti-integrin molecule) and tofacitinib (a JAK inhibitor)
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