Abstract
From 1988 to 1996 there have been at least 17 reports on Creutzfeldt-Jakob disease (CJD) related to the placement of dura mater grafts of cadaveric origin during the course of neurosurgical procedures. The knowledge of means of transmission in the neurosurgical milieu, the changes introduced in the procurement and sterilization of grafts of human origin, and especially the widespread utilization of autologous tissues in dural repair, seems to have put to an end to this feared neurosurgical complication. Probably, we will see in the future only sporadic and infrequent cases of this entity. The authors review their personal experience, published and unpublished data on iatrogenic CJD cases, and the methods in use for eradication of this disease, in which the neurosurgeons have been involuntary protagonists and vectors. We also note the role played by neurosurgeons in the active investigation of most cases, and in contributing to halt CJD spread in the surgical environment.
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