Enfermedad cerebrovascular como síntoma inicial de meningoencefalitis tuberculosa en la infancia

Abstract

The prevalence of tuberculosis in developing countries, such as Brazil, remains high with important morbidity and mortality rates among children. Neurological complications are frequent and tuberculous meningo-encephalitis (TBM) is the most dreaded of them in infancy. Our case involves a 7-year-old white female patient who was previously in good health. Over a period of two weeks she suffered from high temperatures and vomiting and was given amoxicillin. She later suffered an attack of focal seizures. Electroencephalogram studies showed a temporary double focus and lesions in the left hemisphere. A cranial computerised tomography (CT) scan revealed a periventricular haemorrhage on the left side. The control CT (carried out 20 days later) showed a reduction in the haemorrhage and localised hypodensity. Owing to the suspected existence of an abscess, the patient was administered vancomycin. A new cranial CT scan (40 days after the first) showed gliosis alongside the basal nuclei with impregnation in the carotid trifurcation, which led us to suspect that we were dealing with a case of vasculitis or a granuloma. All the microbacterial cultures were negative and there was no history of contact with tuberculosis. The adenosine deaminase (ADA) value in the sample of cerebrospinal fluid (taken seven weeks after the first) was found to be 21.2 UI. Treatment was started with tuberculostatic compounds. Two weeks later the fever disappeared. The control CT scan showed decreased hypodensity and impregnation. The patient was discharged from hospital, with a slight monoparesis in the upper right limb. The presentation of a cerebrovascular disease within a context of TBM, like the case reported here, is relatively rare in the literature. We concluded that the uncommon initial symptoms of TBM, associated with the negative cultures, contributed to the delay in reaching a diagnosis. A cerebrovascular accident must be included in the clinical picture of TBM and this disease has to be taken into account when dealing with a case of cerebrovascular accident.