Abstract
Purpose: Cancer initialization can be explained as a result of parasitic virus energy consumption leading to randomized genome chemical bonding.Materials and methods: Analysis of experimental data on cell-mediated immunity (CMI) containing about 12,000 cases of healthy humans, cancer patients and patients with precancerous cervical lesions disclosed that the specific cancer and the non-specific lactate dehydrogenase-elevating (LDH) virus antigen elicit similar responses. The specific antigen is effective only in cancer type of its origin but the non-specific antigen in all examined cancers. CMI results of CIN patients display both healthy and cancer state. The ribonucleic acid (RNA) of the LDH virus parasitizing on energy reduces the ratio of coherent/random oscillations. Decreased effect of coherent cellular electromagnetic field on bonding electrons in biological macromolecules leads to elevating probability of random genome reactions.Results: Overlapping of wave functions in biological macromolecules depends on energy of the cellular electromagnetic field which supplies energy to bonding electrons for selective chemical bonds. CMI responses of cancer and LDH virus antigens in all examined healthy, precancerous and cancer cases point to energy mechanism in cancer initiation.Conclusions: Dependence of the rate of biochemical reactions on biological electromagnetic field explains yet unknown mechanism of genome mutation.
Highlights
Oncogene mutation is a process of cancer initiation
The involvement of lactate dehydrogenase-elevating (LDH) virus activity in cancer origin has been confirmed by measurements of cell-mediated immunity (CMI) response of T lymphocytes from cancer patients to the AV antigen
The CMI response of T lymphocytes from cancer patients to the non-specific LDH virus and specific cancer antigens very likely detects a decrease of coherence, but not the causes of its decrease
Summary
Oncogene mutation is a process of cancer initiation. Different somatic mutations are analyzed in a number of papers, for instance in Alexandrov et al (2013), Davies et al (2002), Dhomen et al (2009), Dankort et al (2009), Tsai et al (2008) and Vredeveld et al (2012) but understanding the biological processes underlying genome somatic mutations is limited. Coherent mechanical vibrations of the membrane of yeast cells dependent on oxidative energy supply were measured by Pelling et al (2004, 2005). Increase of randomness connected with parasitic energy consumption is assumed to be disclosed by the cellmediated immunity (CMI) measurement based on cancer and the lactate dehydrogenase-elevating (LDH) virus antigens. The immune system provides supervision of essential biological functions of living cells; energy and coherence level of electric polar vibrations in cells should be supervised. The immune response should include assessment of energy transfer from coherent electric polar vibrations to bonding electrons to exclude random chemical reactions. Effective mass and mobility of electrons depend on scattering and interaction with surrounding atoms and their random vibrations, i.e. on processes connected with energy changes. The mobility of electrons in polycrystalline silicon is about 300 cm2/(Vs)
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