Abstract
Energy metabolism and behavior in the corticotropin-releasing factor family of peptides.
Highlights
Specialty section: This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Neuroscience
This year, 2015, will mark the sixtieth anniversary of the seminal work by Guillemin and Rosenberg (1955) and Schally and Saffran (1955) which, along with the earlier work from Geoffrey Harris’ lab, initiated the search for an adrenocorticotropin releasing factor that culminated with the discovery of corticotropin-releasing factor (CRF) in 1981 by Wylie Vale’s laboratory (Vale et al, 1981)
Since the 1980s, the CRF story has had many twists and turns from the finding that CRF and its receptors are located in many extra-hypothalamic brain areas and extending to the discovery that two genome duplications expanded the CRF peptide family hundreds of millions of years ago
Summary
Specialty section: This article was submitted to Neuroendocrine Science, a section of the journal Frontiers in Neuroscience. Six review papers in this volume summarize some of the latest research on the role of CRF and urocortin (UCN) peptides in modulating behavior during stress. Two new research studies present data supporting an ancient role for CRF/UCN receptors in social behavior and feeding, while two additional papers explore the role of extrahypothalamic CRF neurons in behavioral and endocrine responses.
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