Abstract
In Chap. 9, we showed an example of hydration-coupled conformational changes. However, the energy landscape of protein motions including hydration changes remains unexplored. As a future approach to understanding how motions of hydrated proteins occur in solution, here we examine methods of structural analysis that can be used to collect a large number of protein conformations, including their hydration structures, that are necessary for describing the free-energy landscape. Particularly, a set of equations for cryogenic electron microscopy images and molecular dynamics snapshots are derived and applied to illustrate the energy landscape of protein domain motion. Using artificial intelligence-based prediction of hydration structures, conformational transition in the energy landscape, will be illustrated.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
