Abstract
Patients with malignant neoplasms of the bladder or severe anatomical and functional bladder abnormalities are the candidates for cystectomy and orthotopic urine diversion. The distal portion of the ileum is the most frequent anatomical organ, which is used for the formation of the urinary conduit. The formation of a urinary reservoir from the ileum that is unable to perform new functions, and mainly programmed to isolate enzymes, digest food and absorb nutrients, salts and minerals changes the energy exchange in the ileum wall under the influence of urine. The aim of the research is the examination of energy metabolism changes in the ileum wall during the formation of artificial bladder in experimental conditions conducted on mini-pigs. Experimental studies were performed on 21 female mini-pigs with an average age of 6 to 14 months. The duration of the experiment was 12 months. An imbalance of the ATP-ADP-AMP system was observed in the transplant tissue of the graft in different postoperative periods. Changes in the level of ATP are characteristics of the development of tissue ischemia. Results. The values of the adenosine nucleotides sum (the energy potential indicative of the respiration rate of mitochondria) and the phosphorylation index were lower at different times of observation in the transplant tissue. The energy charge value was lower to a lesser extent relative to the control. Conclusion. The revealed changes in the level of adenosine nucleotides confirm the severity of the disturbances of the energy homeostasis in the transplant tissue at all stages of the observation.
Highlights
Patients with malignant neoplasms of the bladder or severe anatomical and functional abnormalities of the bladder may be candidates for cystectomy and orthotopic urine diversion [1, 2]
Aim of research The aim of investigation is the examination of energy metabolism changes in the ileum wall during the formation of artificial bladder in experimental conditions conducted on mini-pigs
The experimental model of the artificial bladder was reproduced by performing cystectomy in animals with ileocystoplasty in anesthesia
Summary
Patients with malignant neoplasms of the bladder or severe anatomical and functional abnormalities of the bladder may be candidates for cystectomy and orthotopic urine diversion [1, 2]. The intestine transplant has the properties of resorption of urine components with the development of hyperchloremic acidosis, possibly urodynamic disorders of the upper urinary tract and the progression of renal failure, which complicates the course of the long-term postoperative period in the initially severe and age-related contingent of patients [7, 8]. The formation of a urinary reservoir from the ileac part, which is unable to perform new functions, and programmed to isolate enzymes, digest and absorb nutrients, salts and minerals, may change the energy exchange in the ileum wall during contact with urine. The metabolic processes in the wall of the neobladder have not been sufficiently studied during a certain period under the influence of new conditions of functioning [10, 11]
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