Abstract
The use of indirect calorimetry is strongly recommended to guide nutrition therapy in critically ill patients, preventing the detrimental effects of under- and overfeeding. However, the course of energy expenditure is complex, and clinical studies on indirect calorimetry during critical illness and convalescence are scarce. Energy expenditure is influenced by many individual and iatrogenic factors and different metabolic phases of critical illness and convalescence. In the first days, energy production from endogenous sources appears to be increased due to a catabolic state and is likely near-sufficient to meet energy requirements. Full nutrition support in this phase may lead to overfeeding as exogenous nutrition cannot abolish this endogenous energy production, and mitochondria are unable to process the excess substrate. However, energy expenditure is reported to increase hereafter and is still shown to be elevated 3 weeks after ICU admission, when endogenous energy production is reduced, and exogenous nutrition support is indispensable. Indirect calorimetry is the gold standard for bedside calculation of energy expenditure. However, the superiority of IC-guided nutritional therapy has not yet been unequivocally proven in clinical trials and many practical aspects and pitfalls should be taken into account when measuring energy expenditure in critically ill patients. Furthermore, the contribution of endogenously produced energy cannot be measured. Nevertheless, routine use of indirect calorimetry to aid personalized nutrition has strong potential to improve nutritional status and consequently, the long-term outcome of critically ill patients.
Highlights
The optimal quantity and timing of nutrition support for critically ill patients has long been debated
There is a clear understanding that over- and underfeeding are associated with worse outcome, optimization of nutrition support is impeded by a lack of insight into the variable nutritional needs of critically ill patients during Intensive care unit (ICU) stay and convalescence, both on a group and individual level [1, 8, 14]
The most recent study by Jonckheer et al [72] in 10 critically ill ventilated patients treated with Continuous venovenous hemofiltration (CVVH) found that Carbon dioxide (CO2) alterations due to CVVH are of no clinical importance, so no correction factor for Resting energy expenditure (REE) is needed with or without CVVH
Summary
The optimal quantity and timing of nutrition support for critically ill patients has long been debated. Indirect calorimetry (IC) is considered the gold standard to measure caloric needs in critically ill patients at bedside, and its use has been strongly recommended by the recent European Society for Clinical Nutrition and Metabolism (ESPEN) and American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines [1, 16, 18, 22].
Full Text
Topics from this Paper
Use Of Indirect Calorimetry
Indirect Calorimetry
Energy Expenditure
Full Nutrition Support
Exogenous Nutrition
+ Show 5 more
Create a personalized feed of these topics
Get StartedTalk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Similar Papers
The Journal of Pediatrics
Jul 1, 2011
Journal of Parenteral and Enteral Nutrition
Apr 27, 2009
Clinical Nutrition Experimental
Oct 1, 2020
Clinical Nutrition
Jun 1, 2017
Current Opinion in Clinical Nutrition and Metabolic Care
Jan 1, 1999
Current Opinion in Clinical Nutrition & Metabolic Care
Sep 1, 2018
Current Opinion in Critical Care
May 14, 2021
Chinese Journal of Bases and Clinics in General Surgery
Oct 30, 2011
Neurosurgery
Aug 1, 1992
Apr 30, 2010
Frontiers in Pediatrics
Oct 24, 2022
Frontiers in Pediatrics
Oct 24, 2022
Journal of Intensive Care
Journal of Intensive Care
Nov 20, 2023
Journal of Intensive Care
Nov 20, 2023
Journal of Intensive Care
Nov 17, 2023
Journal of Intensive Care
Nov 16, 2023
Journal of Intensive Care
Nov 15, 2023
Journal of Intensive Care
Nov 13, 2023
Journal of Intensive Care
Nov 13, 2023
Journal of Intensive Care
Nov 9, 2023
Journal of Intensive Care
Nov 9, 2023
Journal of Intensive Care
Nov 8, 2023