Abstract
The influx of 42K + into isolated heart mitochondria under conditions of steady-state K + was examined using both centrifugation and Millipore filtration procedures. The influx shows saturation kinetics with a rather high K m (12 mM) and low V (3–7 nmol of K +·min −1·mg −1). Influx requires respiration and is sensitive to uncouplers. It is inhibited competitively by Mg 24+ and is strongly activated by P i, by elevated pH, and by thiol-group reagents such as mersalyl. The influx of 42K + in the presence of P i is strongly inhibited by the addition of ADP to initiate phosphorylation.
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