Endovascular treatment of cerebellar arteriovenous malformations: A single-center experience of 75 consecutive patients.

Abstract

We aimed to determine the safety and effectiveness of endovascular treatment for cerebellar arteriovenous malformations (AVMs). Between January 2006 and January 2016, 75 patients with cerebellar AVMs underwent endovascular treatment at our department. The clinical and angiographic features, post-procedure complications, occlusion rate, and follow-up outcomes (modified Rankin Scale, mRS) of all the patients were retrospectively reviewed and collected. Multivariable logistic analysis was used to calculate potential risk factors for predicting poor outcomes (mRS ≥3). Of the 75 patients, 61 (81.3%) presented with initial hemorrhage, and 44 (58.7%) presented with 63 cerebral aneurysms. Immediate digital subtraction angiography (DSA) after the procedure showed complete occlusion of the cerebral aneurysms in all the patients, and total occlusion of the AVM nidus in 32/75 (42.7%) patients, 99-90% occlusion in 31/75 (41.3%) patients, and <90% occlusion in 12/75 (16.0%) patients. Favorable functional outcome (mRS <3) was achieved in 61 (81.3%) patients. After adjusting for other factors, multivariate logistic analysis showed that increasing patient age (OR, 1.086; 95% CI, 1.098-1.182), the size of AVM (OR, 9.072; 95% CI, 1.164-20.703), and eloquent location (OR, 9.209; 95% CI, 1.557-35.481) were significantly independent predictors of poor outcome. Endovascular treatment of cerebellar AVMs is safe and feasible. The high rate of associated cerebral aneurysms could explain the tendency of initial hemorrhage in cerebellar AVMs; targeted embolization of coexisting cerebral aneurysms should be the first priority. Increasing patient age, eloquent AVM location, and the size of AVM are independent predictors of poor outcome after endovascular treatment of cerebellar AVMs.