Abstract
Schwein and co-authors described a scientifically elegant porcine model of deep vein thrombosis (DVT) that employs a transient three balloon occlusion of the bi-iliocaval segment followed by administration of thrombin into the occluded segment.1 Large animal models are crucial as an effective model for DVT in humans, as they differ less in anatomy and physiology than smaller animals. The first endovascular large animal models of venous thrombosis (VT) were described two decades ago.2 The major advantage of the novel model is the preservation of the structural integrity of the vein wall and the endothelial lining.
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More From: European Journal of Vascular & Endovascular Surgery
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