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Abstract
61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. Four different endotypes have been identified, including entopic, which can be the basis for new approaches to the diagnosis and treatment of allergic rhinitis and asthma.
Highlights
61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests
A cohort of atopic patients of both sexes was studied in order to identify different endotypes and differentiate different therapeutic approaches associated with antigen-specific therapy and topical glucocorticoids
It was established that the classical atopic endotypes were in total characterized by high serum concentration of polyspecific IgE, general Th2 polarization, the frequency of positive allergy skin tests, and atopic family heredity
Summary
61 people suffering from persistent allergic rhinitis and asthma accompanying food allergies were studied using case histories, the NHANES questionnaire, polyspecific serum levels, allergen-specific IgE, IL4, IFNg and IL10 assays, and allergy skin tests. The authors declare that there were no conflicts of interest related to this publication. For citation: Klimov A.V., Isaev P.Yu., Klimov V.V., Sviridova V.S. Endotypes of allergic rhinitis and asthma accompanying food allergy.
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