Year-end Sale % OFF 
Abstract
52 Endotracheal Naloxone in Rabbits: No Adverse Effects on Blood Gases and Lung Tissue SC Rector, RW Geiss, K Beamer, P Legg/Emergency Service, and Departments of Surgery and Pathology, West Virginia School of Medicine, Morgantown We compared endotracheal naloxone with normal saline solution to study the effects on arterial blood gases and lung tissue in 16 rabbits. The pulmonary effects of endotracheal naloxone have not been studied previously. Eight rabbits received naloxone through an endotracheal tube, and eight controls received normal saline. Blood gases were sampled for 30 minutes. Four subject rabbits and four controls were killed after two days; the remaining rabbits were killed after six weeks. Microscopic analysis of lung tissue was done by a pathologist blinded to the identity of the specimens. There was no significant difference in blood gas values between the naloxone and control groups. By microscopy, there was no observed pattern of variance in pulmonary pathology between the subject and control groups. This experiment revealed no adverse effects on rabbit blood gases and lung tissue after one dose of endotracheal naloxone as compared with saline. Further study is needed before endotracheal naloxone can be considered safe for human use.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
