Abstract
Endotoxaemia in Obstructive Jaundice
Highlights
Surgical procedures in patients with obstructive jaundice are associated with significant morbidity and mortality[1]
The recognition of endotoxaemia as a possible cause of complications in obstructive jaundice and other pathological situations has led to the development of a variety of therapeutic strategies, including the use of anti-endotoxin agents, and these will be discussed
Impaired Kupffer Cell Activity burns, systemic administration of endotoxin and obstructive jaundice[43,44,45]. It seems from some of these studies that circulating endotoxin itself is one of the factors which can alter gut permeability and in obstructive jaundice, lack of bile flow and other factors predispose to portal absorption of endotoxin and impaired reticuloendothelial function allows systemic endotoxaemia to develop
Summary
Surgical procedures in patients with obstructive jaundice are associated with significant morbidity and mortality[1]. This is due, to a large extent, to the development of postoperative complications such as sepsis, bleeding disorders and renal failure[24]. The focus of this review will be the proposed association between the presence of systemic endotoxaemia in obstructive jaundice and the subsequent development of systemic complications. The recognition of endotoxaemia as a possible cause of complications in obstructive jaundice and other pathological situations has led to the development of a variety of therapeutic strategies, including the use of anti-endotoxin agents, and these will be discussed
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