Abstract
The effect of histamine on the isolated rat common carotid, renal and cranial mesenteric arteries was examined. Histamine (10(-8)-10(-4) M) caused concentration-dependent relaxations of the arteries during contractions induced with phenylephrine (10(-8)-10(-7) M). Removal of the vascular endothelium inhibited the histamine-induced relaxations. Pyrilamine (6 X 10(-6) M), but not metiamide (10(-6) M), abolished the relaxant effect of histamine. Moreover, pyrilamine (6 X 10(-6) M) did not affect endothelium-dependent relaxations of the arteries produced with acetylcholine. These results indicate that histamine causes endothelium-dependent relaxations of the rat peripheral large conduit arteries, which appeared to be mediated via H1-histaminergic receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives Internationales de Physiologie et de Biochimie
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
