Abstract
Were studied endothelioprotective and antiaggregant properties of Primula veris L. solid herbal extract (PVSHE) in animals under experimental chronic heart failure (CHF) caused by isoproterenol administration in a dose of 2,5 mg / kg twice a day for 21 days. It was shown that in the control group of animals with CHF, the introduction of acetylcholine increased by 21,2 %, while the non-selective NO-synthase inhibitor L-NAME reduced the rate of blood flow in the carotid artery of rats by 27,5 %, which was less than the same values in the intact group: 45,2 % and -46,8 %, respectively (p < 0,05). The introduction of acetylcholine caused an increase in the rate of blood flow in the carotid artery in rats with CHF who received PVSHE at a dose of 30 mg / kg by 43,4 % and mildronate at a dose of 50 mg / kg - by 43,8 %, which was significantly higher than in animals of the control group (p < 0,05). The non-selective inhibitor of NO-synthase L-NAME reduced blood flow in the animals with CHF receiving study medications: -40,4 % and -39,5 % (p < 0,05), respectively It was found that the rate and degree of aggregation of platelets was higher in rats with CHF than in intact animals (29,6 % / min versus 20,6 % / min and 27,3 % vs. 18,8 %, p < 0,05, respectively ). In rats with CHF receiving PVSHE, the rate of blood flow in the carotid artery was 20% / min, mildronate -23,2 % / min, the degree of aggregation was 19 % and 21,9 %, respectively which was significantly lower in comparison with animals of the control group (p < 0,05). It was found that the level of von Willebrand factor (vW) was higher in animals with CHF than in the intact group by 91,1 % (p < 0.05) and significantly lower in animals with CHF who received PVSHE by 31,4 % (p < 0,05) and mildronate 21,2 % relative to the control group of rats (p < 0,05). The obtained data testify to the endothelioprotective and antiaggregant effect of the PVSHE comparable to the comparative preparation mildronate.
Highlights
ENDOTHELIOPROTECTIVE AND ANTIAGGREGANT EFFECT OF PRIMULA VERIS L
It was shown that in the control group of animals with chronic heart failure (CHF), the introduction of acetylcholine increased by 21,2 %, while the non-selective NO-synthase inhibitor L-NAME reduced the rate of blood flow in the carotid artery of rats by 27,5 %, which was less than the same values in the intact group: 45,2 % and -46,8 %, respectively (p < 0,05)
The introduction of acetylcholine caused an increase in the rate of blood flow in the carotid artery in rats with CHF who received PVSHE at a dose of 30 mg / kg by 43,4 % and mildronate at a dose of 50 mg / kg – by 43,8 %, which was significantly higher than in animals of the control group (p < 0,05)
Summary
Изучены эндотелиопротекторные и антиагрегантные свойства густого экстракта из травы первоцвета весеннего (ГЭТПВ) у животных при экспериментальной хронической сердечной недостаточности (ХСН), вызванной введением изопротеренола в дозе 2,5 мг/кг 2 раза в день в течение 21 дня. Введение ацетилхолина вызывало увеличение скорости кровотока в сонной артерии у крыс с ХСН, получавших ГЭТПВ в дозе 30 мг/кг на 43,4 % и милдронат в дозе 50 мг/кг – на 43,8 %, что было существенно больше, чем у животных контрольной группы (р < 0,05). Что скорость и степень агрегации тромбоцитов была выше у крыс с ХСН по сравнению с интактными животными (29,6 %/мин против 20,6 %/мин и 27,3 % против 18,8 %, р < 0,05 соответственно). У крыс с ХСН, получавших ГЭТПВ, скорость кровотока в сонной артерии была равна 20 %/мин, милдронат -23,2 %/мин, степень агрегации – 19 % и 21,9 % соответственно, что было значительно ниже в сравнении с животными с ХСН контрольной группы (р < 0,05). Густой экстракт из травы первоцвета весеннего (ГЭТПВ) является богатым источником полифенольных соединений, обладающих антиоксидантной активностью [4], что позволяет предположить наличие у него эндотелиопротекторных и антиагрегантных свойств
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