Abstract
BackgroundExercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood. Endothelins are proinflammatory, profibrotic, broncho- and vasoconstrictive peptides which play an important role in the development of airway inflammation and remodeling in asthma. The aim of the study was to evaluate the changes in endothelin-1 levels in exhaled breath condensate following intensive exercise in asthmatic patients.MethodsThe study was conducted in a group of 19 asthmatic patients (11 with EIB, 8 without EIB) and 7 healthy volunteers. Changes induced by intensive exercise in the concentrations of endothelin-1 (ET-1) in exhaled breath condensate (EBC) during 24 hours after an exercise challenge test were determined. Moreover, the possible correlations of these measurements with the results of other tests commonly associated with asthma and with the changes of airway inflammation after exercise were observed.ResultsIn asthmatic patients with EIB a statistically significant increase in the concentration of ET-1 in EBC collected between 10 minutes and 6 hours after an exercise test was observed. The concentration of ET-1 had returned to its initial level 24 hours after exercise. No effects of the exercise test on changes in the concentrations of ET-1 in EBC in either asthmatic patients without EIB or healthy volunteers were observed. A statistically significant correlation between the maximum increase in ET-1 concentrations in EBC after exercise and either baseline FENO and the increase in FENO or BHR to histamine 24 hours after exercise in the groups of asthmatics with EIB was revealed.ConclusionThe release of ET-1 from bronchial epithelium through the influence of many inflammatory cells essential in asthma and interactions with other cytokines, may play an important role in increase of airway inflammation which was observed after postexercise bronchoconstriction in asthmatic patients.
Highlights
Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition, whose pathophysiology is not well understood
We revealed statistically significant higher levels of ET-1 in exhaled breath condensate (EBC) in all studied asthmatic patients compared with healthy controls (0.83 fmol/ml ± 0.24 vs. 0.59 ± 0.18, p = 0.02)
This study was performed to clarify the possible role of ET1 in the pathogenesis of EIB, particular in the inflammatory basis of this condition and the remodeling of the airways
Summary
The aim of the study was to evaluate the changes in endothelin-1 levels in exhaled breath condensate following intensive exercise in asthmatic patients. The aim of the study was to evaluate the changes in ET-1 in EBC following intensive exercise in asthmatic patients and to establish the possible correlation of these measurements with the parameters of airway inflammation and their changes after exercise. The aim of the present study was the assessment of the changes of ET-1 levels in EBC during the first 24 hours after postexercise bronchoconstriction
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