Abstract
The effect of endothelin on aldosterone production by dispersed adreno-capsular cells from rabbits was examined. Porcine endothelin stimulated aldosterone production dose-dependently with an EC 50 of 5 × 10 −14 M, but had no effect on corticosterone production. A calcium channel blocker, nicardipine, completely inhibited the stimulatory effect of endothelin on aldosterone production. Endothelin induced prompt and sustained increase in intracellular Ca 2+ in fura-2-loaded cells, and nicardipine inhibited this increase in intracellular Ca 2+. These results indicate that endothelin stimulates aldosterone biosynthesis in dispersed zona glomerulosa cells of rabbits, and that its effects is related to increase in intracellular calcium through voltage-dependent calcium channels.
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