Abstract
The present study tests whether endothelin ET B receptor activation can mediate endothelin-1 constriction in the rabbit basilar artery in situ. Endothelin-1 (30 nM) induced 27% constriction of vessels pretreated with 1 μM BQ610 (homopiperidenyl-CO-Leu- d-Trp (CHO)- d-Trp-OH), an endothelin ET A receptor antagonist, and the resulting constriction was completely relaxed by BQ788 ( N- cis-2,6-dimethylpiperidinocarbonyl l- γ-MeLeu- d-Trp (COOCH 3)–Nle), an endothelin ET B receptor antagonist. Similarly, 30 nM endothelin-1 induced 30% constriction of vessels pretreated with 1 μM BQ788, and the resulting constriction was completely relaxed by BQ610. In contrast, sarafotoxin S6c, an endothelin ET B receptor agonist, did not induce constriction. This study suggests that in the basilar artery (1) endothelin ET B receptor activation can result in constriction and (2) the ability to elicit constriction is in some way dependent upon the agonist that activates the endothelin ET B receptor.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
