Abstract
The study was conducted to determine whether endothelin (ET)-receptor antagonism affects blood pressure in spontaneously hypertensive rats (SHRs) during pregnancy. Sixteen pregnant rats were given bosentan (Ro 47-0203/029), a nonspecific ET A/ET B antagonist, at a dose of 100 mg/kg of body weight. Fourteen untreated pregnant rats served as controls. Body weight, systolic blood pressure, and plasma ET levels were measured 3 times during the pregnancy and once 3 to 5 days after delivery. Blood pressure was measured using the indirect tail-cuff method with an electrosphygmomanometer and a pneumatic pulse transducer. The expected decrease in blood pressure during pregnancy occurred in both the bosentan-treated and the untreated animals. The plasma ET level in the bosentan-treated group increased 8 days after starting treatment and decreased after delivery. The plasma ET level remained unchanged in the untreated animals until after delivery, when it increased. ET does not appear to play a significant role in the maintenance of blood pressure in pregnant SHRs.
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