Abstract
As the prostate adenocarcinoma is one of the most common malignant tumors in males, looking for a marker to effectively predict aggressiveness and metastatic potential in an apparently localized cancer in initial needle biopsy specimens can help the clinicians to make more appropriate decision for treatment, planning, and choosing appropriate targeted therapy. The present study assessed the value of Endothelin-1 expression to predict prognosis of prostatic cancer. In a cross sectional study, 83 patients who underwent radical prostatectomy in Hasheminejad Kidney Center in 2008 through 2012 were assigned to two groups including 43 with and 40 without extra-prostatic extension (EPE). Endothelin-1 staining was performed on Paraffin Embedded blocks of preoperative needle biopsies. The expression of Endothelin-1 increased in 72% of patients in the group with EPE (P<0.001). The group with Endothelin-1 positivity showed higher serum level of prostate specific antigen (PSA) (p = 0.039). Endothelin-1 expression was positive in 67% of patients with perineurial invasion (P<0.001). Adjusting the baseline variables of PSA and PN in a multivariable logistic regression model, the Endothelin-1 positivity could effectively predict EPE in patients with prostatic cancer (OR: 5.46, p = 0.010). Correlation of Endothelin-1 expression in needle biopsy specimens in expected with extra-prostatic extension of tumor in radical prostatectomy specimens, perineurial invasion and serum PSA level at the time of diagnosis.
Highlights
According to annually published National early detect, serum level of prostate specific antigenCancer Registration Report 2008-2009 of Iran,(PSA) in combination with digital rectal exam are prostate cancer is the fourth most frequent cancer used for suspected patients who referred for among male adults with an annual cause of death in Ultrasound-Guided Transrectal Needle Biopsy [4].4.5 per 100,000 men in Iran [1,2,3]
We aimed to investigate the association of Endothelin-1 expression by immunohistochemistry (IHC) on needle biopsies with different prognostic factors of prostatic cancer including extra-prostatic extension in radical prostatectomy specimens, serum level of PSA, and Gleasons score of the tumor
Multivariate logistic regression analysis was performed to assess the role of positive Endothelin1 to predict extra-prostatic extension (EPE)
Summary
According to annually published National early detect, serum level of prostate specific antigenCancer Registration Report 2008-2009 of Iran,(PSA) in combination with digital rectal exam are prostate cancer is the fourth most frequent cancer used for suspected patients who referred for among male adults with an annual cause of death in Ultrasound-Guided Transrectal Needle Biopsy [4].4.5 per 100,000 men in Iran [1,2,3]. As there are no Preoperative PSA level, TNM staging, Gleason integrated national programs for screening and grade and surgical margins are considered as recording of prostate cancer, the incidence rate of major prognostic factors for prostate carcinoma. This cancer might be more than these registered data. Despite the relatively high prevalence of histologic type and DNA ploidy analysis and some this cancer in our region, most patients remained biologic markers including ki, p53, and p21 [5]. One of the interesting and challenging biomarkers that manifested by weight loss, urinary tract is Endothelin-1 (ET-1). Endothelin-1 is produced obstruction and skeletal bone pains. To screen and by many different cell types [6], including prostatic
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