Abstract
Aim. To assess the effect of the 24-week antihypertensive therapy with fixed-dose drug combination (lisinopril plus amlodipine) on endothelial dysfunction and renal function in patients with arterial hypertension (HT) and diabetes mellitus (DM) type 2. Material and methods. 30 hypertensive patients with DM type 2 (aged 40-65 years) were included into the study. Endothelial function (plasma and vascular components) and renal function were studied. Results. Combined antihypertensive therapy significantly improved parameters of endothelial function in patients with HT and DM type 2: production of nitric oxide (NO) in blood serum and urine increased by 122.8% and 65.8%, respectively. Along with these secretion of endothelin (ET-1) in serum and urine decreased by 26.1% and by 76.1%, respectively, p<0.05. A statistically significant redistribution of patients by type of microcirculation was established: the share of patients with normal type of microcirculation increased by 73.4%. There was a statistically significant reduction of proteinuria and albuminuria by 58% and 43.6%, respectively. The share of patients with chronic kidney disease with an estimated GFR 30-60 ml/min/1.73 m2 decreased by 16.7%. Conclusions. It has been shown that the prescription of a long-term antihypertensive therapy with dose-fixed combination (lisinopril plus amlodipine) is safe and effective for endothelial function improvement, including renal endothelium, with no negative effect on glucose and lipid metabolism in patients with HT and DM type 2.
Highlights
Combined antihypertensive therapy significantly improved parameters of endothelial function in patients with HT and diabetes mellitus (DM) type 2: production of nitric oxide (NO) in blood serum and urine increased by 122.8% and 65.8%, respectively
A statistically significant redistribution of patients by type of microcirculation was established: the share of patients with normal type of microcirculation increased by 73.4%
It has been shown that the prescription of a long-term antihypertensive therapy with dose-fixed combination is safe and effective for endothelial function improvement, including renal endothelium, with no negative effect on glucose and lipid metabolism in patients with HT and DM type 2
Summary
Волгоградский государственный медицинский университет. 400131, Россия, Волгоград, пл. Оценить влияние 24-недельной антигипертензивной терапии фиксированной комбинацией лизиноприла с амлодипином на эндотелиальную дисфункцию (ЭД) и функциональное состояние почек у больных артериальной гипертензией (АГ) и сахарным диабетом (СД) 2 типа. Что назначение длительной антигипертензивной терапии фиксированной комбинацией лизиноприла с амлодипином является безопасным и высокоэффективным в восстановлении функции эндотелия, в том числе и почечного, у больных АГ и СД 2 типа, не оказывает негативного влияния на углеводный и липидный обмены. Endothelial-tropic and nephroprotective effects of combined antihypertensive therapy in patients with type 2 diabetes mellitus M.E. Statsenko*, M.V. Derevyanchenko, M.N. Titarenko, O.R. Pastuchova Volgograd State Medical University. Aim. To assess the effect of the 24-week antihypertensive therapy with fixed-dose drug combination (lisinopril plus amlodipine) on endothelial dysfunction and renal function in patients with arterial hypertension (HT) and diabetes mellitus (DM) type
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
