Abstract
The article by Toppila et al 1 in this issue of The American Journal of Pathology raises the provocative possibility that the adhesion molecule L-selectin may play a significant role in the recruitment of lymphocytes to human heart allografts during rejection. The case made by these authors relies strongly on current knowledge about the high-endothelial-venule-expressed ligands (HEV ligands) for L-selectin, which participate in the constitutive homing of lymphocytes to secondary lymphoid organs. The purpose of this Commentary is to summarize and update this rapidly evolving field.
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