Abstract
Large artery endothelial integrity and repair is an important area of investigation in atherosclerosis research. The development of an atherosclerotic plaque (fibrofatty plaque) is a dynamic and complex process that is closely associated with the structure and dysfunction of endothelial cells. Although the sequence of events that lead to the initiation and growth of fibrofatty atherosclerotic plaques is not well understood, there is much experimental and clinical support for the concept that disruption of structural and functional endothelial integrity plays an important role in atherogenesis.
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