Abstract
To evaluate endothelial injury in peritoneal dialysis patients with ultrafiltration failure (UFF), we performed a modified peritoneal equilibration test utilizing 3.86% glucose in 41 patients who had been on peritoneal dialysis for longer than 4 years. Twelve patients whose net ultrafiltrate was less than 400 mL during a 4‐hour exchange were assigned to the UFF group and another 29 patients to the control group. The blood levels of vWF, a marker of endothelial injury, albumin, and lipid profile were measured. The number of antihypertensive medications and amount of 3.86% solution used were higher in the UFF group than those used in the control group (p < 0.05, p < 0.001, respectively). The patients in the UFF group had a significantly higher vWF level than those in the control group (164.8 ± 23.1% vs. 144.5 ± 22.4%, p < 0.05). These results showed that peritoneal dialysis patients with ultrafiltration failure had more severe endothelial injury than those without.
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