Endothelial glycocalyx as an orchestrator of vascular homeostasis. New research problems and prospects for vessel wall protection

Abstract

The functions of endothelial glycocalyx as a regulator of plasma homeostasis and vessel wall homeostasis were considered. The state-of-the-art data of glycocalyx damage by some pathological processes were integrated. The topical task for protection and restoration of the damaged glycocalyx by therapeutic means was formulated. The research approaches for the search for such agents were surveyed and good prospects of multi-disciplinary development of the agents by specialists in different fields were emphasized.