ENDOTHELIAL DYSFUNCTION IN RYAZAN REGION INHABITANTS — PREVALENCE AND RISK FACTORS (BY THE DATA FROM MERIDIAN-RO)

Abstract

Aim. To study the prevalence of endothelial dysfunction in economically active inhabitants of Ryazan region and to reveal the factors influencing the value, including specific for men and women. Material and methods. MERIDIAN-RO was performed as open prospective transcrossing study. Into the study the persons of the age 25-64 y.o. included at the moment of the study, who signed the informed consent. All participants underwent questionnaire filling in by the standard, antropometry, BP, HR measurement, ECG, blood specimens collection to study blood chemistry. Also the complex risk estimation was performed with SCORE (Systematic COronary Risk Evaluation) adapted for Russian Federation. Results. The data showed high prevalence of ED in Ryazan region inhabitants (51,8%) independently from gender, that witnesses the higher risk of atherosclerosis development and it-related diseases. The analysis showed that following influences the ED development: decrease of glomerular filtration rate less than 50 ml/min, C-r.p.>5 mg/ml, fibrinogene>4 g/L, obesity, excessive alcohol consumption, arterial hypertension, SCORE>5%. In gender analysis the specific factors were revealed. So, for men the main role played excessive alcohol drinking (more than 20 ml/day by ethanol) and the level of ApoB more than 100 g/L. For women the main factors were total cholesterol more than 5 mmol/L, apolipoproteine B vore than 100 g/L, fibrinogene more than 4 g/L and diabetes mellitus. Taking into account that the data of MERIDIAN-RO and Ryazan region population are relevant to each other, it is possible to transgress the data of the study to Ryazan region population. Conclusion. Prevalence of ED in Ryazan region population is the same high in men and in women (52,4% vs. 51,2%). The main factors, associated with ED are C-r.p.>5 mg/ml, obesity, arterial hypertension, high risk by SCORE>5%. Also in men the risk factors were: excessive alcohol consumption and ApoB >100 g/L; in women — Apo B >100 g/L, fibrinogene >4 g/L, total cholesterol >5 mmol/L.