Endothelial dysfunction in patients with non-alcoholic fatty liver disease

Abstract

Purpose of the study: The aim of the studyis to study the vascular response in response to a test of reactive hyperemia in patients with NAFLD and to identify the relationship of fatty liver damage with endothelial dysfunction. Methods: The study was conducted on the basis of the Irkutsk Regional Order of the Badge of Honor Clinical Hospital, the Angarsk City Clinical Hospital No. 1 and the Consultative and Diagnostic Department No. 1 of the Irkutsk Regional Infectious Diseases Clinical Hospital. Object of study: patients with NAFLD and practically healthy volunteers. All respondents underwent indirect elastometry to diagnose liver fibrosis, and to assess endothelial dysfunction, a sample of reactive hyperemia according to the Celermajer method [15]. Statistical analysis of the data obtained was performed in the program Statistica 13 for Windows. Results: The study was conducted in the period 2014-2016. Examined 64 people aged 25 to 64 years with a confirmed diagnosis of NAFLD and 23 practically healthy volunteers aged 25 to 44 years included in the clinical comparison group. Conclusions: 1. Fibrous changes in the liver were more common among middle-aged people and were more pronounced than among younger people; 2. The correlation of fatty liver damage with endothelial dysfunction was revealed - the greater the degree of fibrosis, the stronger the pathological reaction of the vascular wall; 3. The presence of endothelial dysfunction in steatosis has been proven, and, accordingly, the risk of cardiovascular events. Conclusion: the results obtained indicate the connection of pathological processes: liver damage in NAFLD and the development of CVD.