Abstract
The vascular complications of diabetes mellitus impose a huge burden on the management of this disease. The higher incidence of cardiovascular complications and the unfavorable prognosis among diabetic individuals who develop such complications have been correlated to the hyperglycemia-induced oxidative stress and associated endothelial dysfunction. Although antioxidants may be considered as effective therapeutic agents to relieve oxidative stress and protect the endothelium, recent clinical trials involving these agents have shown limited therapeutic efficacy in this regard. In the recent past experimental evidence suggest that endoplasmic reticulum (ER) stress in the endothelial cells might be an important contributor to diabetes-related vascular complications. The current paper contemplates the possibility of the involvement of ER stress in endothelial dysfunction and diabetes-associated vascular complications.
Highlights
Diabetes mellitus (DM) is a growing metabolic disease that continues to be a leading health problem worldwide
The current paper suggests the role of diabetesmediated endoplasmic reticulum (ER) stress in the endothelial cell dysfunction and accompanying cardiovascular diseases in diabetes
These possible links between hyperglycemia-induced ER stress and oxidative stress might offer the premises for conducting additional experiments to establish a unified molecular mechanism and thereby identify a potential therapeutic target in reducing vascular complications in diabetes
Summary
Diabetes mellitus (DM) is a growing metabolic disease that continues to be a leading health problem worldwide. The World Health Organization (WHO) has estimated that there are currently 346 million people affected by diabetes worldwide and anticipates that diabetes-related deaths would double by 2030 [1]. These figures highlight the importance of continued research and the need for novel methods to both prevent and treat this pandemic. While diabetes management has largely focused on control of hyperglycemia, the rising burden of this disease is mainly correlated to its vascular complications [2, 3]. The following sections of this paper will provide evidence on the molecular mechanisms of endothelial dysfunction in diabetes with special reference to the role of hyperglycemia/oxidative stress-induced ER stress in the endothelium
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