Abstract
Background Perivascular adipose tissue (PVAT) has been shown to be an important modulator of vascular function through release of both relaxing and contracting factors. However, the involvement of PVAT in development of endothelial dysfunction is not well understood, yet. We have recently demonstrated that mice lacking adipose triglyceride lipase (ATGL) suffer from severe endothelial dysfunction. Since vessels of these mice are coated with large amounts of PVAT, we speculated that this might potentially contribute to disturbed vascular homeostasis. Therefore, PVAT of wild type (WT) and ATGL knockout mice was characteri-zed in terms of inflammatory as well as oxidative stress. Additionally, we wanted to distinguish between
Highlights
Perivascular adipose tissue (PVAT) has been shown to be an important modulator of vascular function through release of both relaxing and contracting factors
We have recently demonstrated that mice lacking adipose triglyceride lipase (ATGL) suffer from severe endothelial dysfunction
Knockout of ATGL resulted in 7-fold increase in PVAT wet weight
Summary
Endothelial dysfunction in adipose triglyceride lipase deficiency: role of perivascular adipose tissue. Marion Mussbacher1*, Karoline Pail, Gerald Wölkart, Günter Hämmerle, Alois Lametschwandtner, Rudolf Zechner, Bernd Mayer, Astrid Schrammel. From 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications Erfurt, Germany. From 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications Erfurt, Germany. 28-30 June 2013
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
