ENDOTHELIAL DYSFUNCTION AND THE PROCESSES OF FREE RADICAL OXIDATION IN PATIENTS WITH PRIMARY AND RECURRENT ISCHEMIC STROKE

Abstract

In the acute phase of recurrent ischemic stroke violations were found in the system of L- arginine - NO, pointing to a weaker response in these patients of endothelium to support the stability of brain tissue to ischemia compared with primary ischemic stroke. The acute phase of recurrent ischemic stroke was supported by a more profound oxidative stress and endogenous intoxication compared to the patients with primary stroke. Changes in the system of L- arginine - NO, LPO (lipid peroxidation) activity and contents of apparent weight molecules at different degrees of severity of both primary and recurrent ischemic stroke in the acute period generally had the same orientation. With the growing severity it was observed an enhancement of endothelial dysfunction and free radical oxidation processes taking place against a background of more marked endogenous intoxication at all degrees of severity of recurrent ischemic stroke.