Abstract
The objective: we aimed to evaluate the relationship between endothelial dysfunction and renal functional in patients with chronic heart failure (CHF) with atrial fibrillation (AF).Materials and methods. 57 patients with CHF NYHA II-III class and preserved left ventricular ejection fraction (LVEF >45%), mean – 60,34 [45, 88]%) aged 45 to 85 years (mean age – 65,49 [45, 85] years) were enrolled. Among 58 patients, more than 65% had endothelial dysfunction.Results. Flow-mediated dilation (FMD) was assessed during reactive hyperemia in all patients, the serum creatinine level was determined and the glomerular filtration rate (GFR) was calculated by CKD-EPI formula.Conclusion. The FMD in patients with CHF with AF was higher by 8,23% than without AF. Deterioration of the renal functional in patients with CHF did not cause significant changes of FMD, however, the presence of AF increased the decrease in FMD (by 13,72%) with a decrease in GFR.
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