Abstract
SummaryObjectivesThe EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia.MethodsTwo hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine.ResultsThe reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001).ConclusionThe EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.
Highlights
Several reports have demonstrated that flow-mediated dilatation (FMD) is significantly reduced in patients with pre-eclampsia when compared with normotensive controls,[18,19,20] confirming that pre-eclampsia is associated with endothelial dysfunction
This study has shown that there is impaired endothelial function in rural African women with pre-eclampsia, based on the low Reactive hyperaemia index (RHI) and increased arterial stiffness, as measured by the baseline pulse-wave amplitude (BPWA) and augmentation index, compared to normotensive pregnancies
This clearly indicates that RHI, BPWA and Alx@75, as measured using the EndoPAT, can be used for assessing endothelial dysfunction in pre-eclampsia
Summary
The EndoPAT method has been used as a noninvasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. Methods: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. Results: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). Conclusion: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia
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