Endothelial Dysfunction and 24-Hour Ambulatory Blood Pressure Monitoring in Patients with Diabetes

Abstract

Abstract Arterial hypertension in patients with diabetes plays a main role in the earlier development of diabetic kidney disease (DKD), and endothelial dysfunction is considered to be a process involved in the development of diabetic complications. It is important to study the markers which gives the opportunity to identify DKD in early stage. In this article is presented a study of 24-hour Ambulatory Blood Pressure Monitoring (24hABPM) data in patients with diabetes and its interconnection with estimated glomerular filtration rate and endothelial dysfunction. The endothelial function was determined using the levels of TGF-b1(transforming growth factor-beta1) and VCAM-1 (vascular cell adhesion molecule-1). In our study, we obtained convincing results that complex including endothelial dysfunction and results of 24hABPM can be considered as early signs of DKD progression in patients with diabetes.