Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark.

Vi Nguyen,Elliott H Chen,Wenbin Tan,Anil G Jegga,J Stuart Nelson,Jacob Kravitz,Harold I Friedman,Yunguan Wang,Marcelo L Hochman,Dongbao Chen,Camilla F Wenceslau,Chao Gao

doi:10.1093/bjd/ljad330

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark.

Vi Nguyen, Elliott H Chen + Show 10 more

Open Access

https://doi.org/10.1093/bjd/ljad330

Copy DOI

Journal: The British journal of dermatology	Publication Date: Sep 6, 2023
Citations: 2

Affiliation: University of South Carolina, Prisma Health, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Charleston Hematology Oncology Associates, Medical University of South Carolina

#Cholesterol Metabolism #Pathological Phenotypes + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.

Full Text