Abstract
Thrombin plays critical roles in both hemostasis and thrombosis. Many studies were carried out to examine the effects of different thrombogenic surfaces on thrombin generation. In the present study, how activated endothelial cells affected platelet thrombin generation under dynamic shear stress was investigated. Human platelets were exposed to pulsatile shear stress (physiological, low or elevated) in a cone-and-plate shearing device for 30 minutes in the presence of quiescent or activated human coronary artery endothelial cells. Coagulation factors including Factor II, Factor Xa and calcium were immediately available.
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