Abstract
The rapid growth in global population continues to challenge the world’s ability to provide enough food. As one of the most crucial issues for human development, food production must increase to offset hunger and poverty as well as social unrest. To augment the yield of crops a variety of pesticides like Endosulfan, Rogor, Aldrin, Chlorpyrifos, etc. are being used liberally by the farmers. In the present investigation, Endosulfan was administered orally (daily) by gavage method to female Swiss albino mice group for 4 weeks @ 3.0 mg/kg b.w. After that, they were left for 6 months and then sacrificed and liver tissues were fixed for light microscopy and Transmission Electron Microscopic study. The histopathological study of Endosulfan administered group liver showed hepatocytes with congestion in central vein with less dense cytoplasm, haemorrhaged bile duct, degenerated cytoplasm and central vein with vacuolations in sinusoidal spaces. Neoplastic changes in hepatocytes are the major finding of study. The ultrastuctural study revealed dilation in the nuclear pore complex and massive movement of cytoplasmic material from cytoplasm to the nucleus which is major finding which denotes neoplastic changes. Presence of abundant free lying polyribosomes in the cytoplasm, which denotes neoplastic changes in the cellis also one of theimportant finding observed. The present study thus deciphers that Endosulfan toxicity leads to onset of neoplasia thence carcinogenesis in liver cells in Swiss albino mice which is the novel finding in the field of toxicology.
Highlights
Food problems have haunted mankind since time immemorial
For the study female Swiss albino mice were procured from the animal house of Mahavir Cancer Institute & Research Centre, Patna, Bihar, India (CPCSEA Regd. no. 1129/bc/07/CPCSEA, dated 13/02/2008) and their ethical approval for this study was obtained by the Institutional Animal Ethics Committee (IAEC)
The highly significant result showed the migration of cytoplasmic material into the nucleus (Figure 7) i.e. nuclear inclusion denotes the neoplastic condition as the nuclear inclusion shows mitochondria with rough endoplasmic reticulum (Figure 8)
Summary
Food problems have haunted mankind since time immemorial. With few technology breakthrough to increase yields, the food needs of growing population were historically met by expanding the cultivated area. Organochlorine (OC) insecticides, used successfully in controlling a number of diseases, such as malaria and typhus, were banned or restricted after the 1960’s in most of the technologically advanced countries. A pesticide must be lethal to the pests, but not to non-target species, including man. This is not so the controversy of use and abuse of pesticides has surfaced. Government of Kerala, India, banned this pesticide (Endosulfan) after its hazardous effect on the reproductive health of Kassaragod district cashew nut workers. Endosulfan exposure had caused lots of health hazards among the cashew nut workers in Kerala, India it thence became a rationale to re-evaluate its carcinogenic effect in animal models. The present study illustrates the carcinogenic activity of Endosulfan on the liver cells of Swiss albino mice
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
