Abstract
The asymmetric 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient alkenes is a powerful and atom-economical method for preparing structurally and stereochemically rich pyrrolidines. Substituted pyrrolidines are prevalent in natural alkaloids, pharmaceuticals, organocatalysts, and biologically important molecules. The authors described that silver(I)/TF-BiphamPhos (1) served as an efficient catalyst for the highly endo-selective 1,3-dipolar cycloaddition of azomethine ylides and vinyl phenyl sulfone with high yield (up to 98%) and high enantioselectivity (up to 92% ee).
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
