Abstract
Objective. Radiofrequency ablation is a well-established antitumor treatment and is recognized as one of the least invasive therapeutic modalities for pancreatic neoplasm. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) delivery can be used to treat both pancreatic cancer and asymptomatic premalignant pancreatic neoplasms and may serve as a less invasive alternative to surgical resection. This is an appealing option that may result in less morbidity and mortality. The aim of this review was to summarize and evaluate the clinical and technical effectiveness of EUS-guided RFA of pancreatic neoplasms. Methods. A through literature review was performed to identify the studies describing this novel technique. In this review article, we have summarized human case series. The indications, techniques, limitations, and complications reported are discussed. Results. A total of six studies were included. Overall, a 100% technical success rate was reported in human studies. Complications related to endoscopic ultrasound-guided radiofrequency ablation delivery have been described; however, few cases have presented life-threatening outcomes. Conclusion. We believe that this novel technique can be a safe and effective alternative approach in the management of selected patients.
Highlights
Pancreatic cancer carries a poor prognosis, with a 5-year overall survival rate of
Though our studies focused on Endoscopic ultrasound-guided radiofrequency ablation (EUS-radiofrequency ablation (RFA)) in the pancreas, the same modality could be used in the liver
EUS-RFA can be used to treat premalignant, asymptomatic, pancreatic lesions instead of surgical resection, and this is promising as surgical procedures are commonly associated with major morbidity and some mortality
Summary
Pancreatic cancer carries a poor prognosis, with a 5-year overall survival rate of
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