Abstract
Autoimmune pancreatitis (AIP) is an inflammatory process that has characteristic clinical, radiographic, and pathologic features but may mimic pancreatic malignancy. In this study, we reviewed our experience in the endoscopic ultrasound-guided fine-needle aspiration evaluation of pancreatic lesions in patients with AIP. We searched the cytopathology archives and identified a total of 6 cases that had endoscopic ultrasound-guided fine-needle aspiration evaluation and subsequent tissue biopsy or resection with a diagnosis of AIP. The clinical, cytologic, and histopathologic features were reviewed. The original cytologic diagnoses included negative, atypical, and suspicious for malignancy in 2 cases each. On retrospective review, these cases were characterized cytologically by the presence of mixed epithelial cells, mixed lymphocytes, and plasma cells, as well as cellular stromal fragments. Cytologic atypia of epithelial cells was observed in 4 of 6 cases, including mild (3 cases) and moderate (1 case) atypia. KRAS mutation analysis was performed in 4 cases with an indeterminate cytology diagnosis, which was negative in all cases. Our results demonstrate that the presence of trilineage epithelial, lymphoplasmacytic, and stromal elements may be suggestive but not definitive for a diagnosis of AIP. The role of KRAS mutation analysis in AIP remains inconclusive and may warrant further evaluation.
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