Abstract
A total of 131 patients with solid pancreatic masses were prospectively enrolled and randomly assigned to undergo endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) with either a 22-gauge or 25-gauge needle [1]. Both study arms were comparable with respect to patient demographics, tumor size and location, and the use of anticoagulants and drugs affecting platelet function. The EUS–FNA was performed in a standard manner with on-site assessment of sample adequacy by a cytology technician. The final cytologic diagnosis was made by a cytologist blinded to the needle size used. For the purpose of the analysis, cytologic findings negative for malignancy, atypical and suspicious were considered nondiagnostic. The gold standard was not specified in the paper. The number of patients without malignancy who were punctured but not included in the analysis (only malignant cases were analyzed) remains unclear.
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