Abstract
IntroductionGanglioneuromas are rare benign peripheral neuroblastic tumors characterized by hyperplasia of ganglion cells, nerve fibers, and supporting cells. They are not usually localized in the colon.Case presentationA 61-year-old Caucasian man was admitted to our department for colon cancer screening. A colonoscopy revealed a lipoma of 5cm in diameter, two micropolyps of less than 1cm, and one sessile polyp of 0.6cm in diameter. The polyps were removed with hot biopsy forceps. A histological examination revealed two hyperplastic polyps and one ganglioneuroma polyp. A follow-up colonoscopy showed no signs of recurrence after 16 months.ConclusionsAlthough a few cases of lipomas associated with ganglioneuromatous syndrome have been reported, the association of an intestinal lipoma with an isolated ganglioneuroma polyp has not been described. The implications of this association are unknown.
Highlights
Ganglioneuromas are rare benign peripheral neuroblastic tumors characterized by hyperplasia of ganglion cells, nerve fibers, and supporting cells
Conclusions: a few cases of lipomas associated with ganglioneuromatous syndrome have been reported, the association of an intestinal lipoma with an isolated ganglioneuroma polyp has not been described
Intestinal GNs have been found in patients with several systemic syndromes such as multiple endocrine neoplasia type IIB (MEN IIB), neurofibromatosis type 1 (NF1), juvenile polyposis, polyposis coli, tuberous sclerosis, and Cowden’s disease [1]
Summary
Ganglioneuromas (GNs) are slow-growing and welldifferentiated neuroectodermal neoplasias. They are derived from developing neuronal cells of the sympathetic nervous system and occur mostly in children. Intestinal GNs have been found in patients with several systemic syndromes such as multiple endocrine neoplasia type IIB (MEN IIB), neurofibromatosis type 1 (NF1) ( known as von Recklinghausen’s disease), juvenile polyposis, polyposis coli, tuberous sclerosis, and Cowden’s disease [1]. We report the case of a patient with synchronous GN and lipoma. Cutaneous and intestinal lipomas have been associated with GN polyposis in a few cases, but the implications of this association are unknown. Case presentation A 61-year-old Caucasian man underwent colonoscopy for colon cancer screening. No abdominal or intestinal symptoms were reported, and his family history,
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