Abstract
Bronchoesophageal Fistula (BEF) is an uncommon condition related to complex thoracic surgery. The development of BEF is usually an indication of the progression of bronchial or lung cancer; whereas the etiology of this illness being recorded as benign is much rarer – not exceeding 4 - 6%. [1, 2]. 
 Surgery is the main method for treating patients who have benign BEF, allowing for the reliable result. At the same time, similar operations are extremely traumatic and are fraught with the development of post-operation complications, especially when concerning patients with genetically determined coagulopathy. 
 Factor V Leiden mutation is a hereditary coagulopathy in which there is a point mutation in the gene that encodes blood coagulation factor V. Factor V Leiden mutation is the most common cause of the hereditary disposition to thrombosis, heart attacks, strokes in Europeans. The frequency of occurence among the population of the USA is 4 – 6% [3]. 
 We present our own observation of successful endoscopic surgery to treat BEF in a patient with Factor V Leiden mutation and chronic pulmonary embolism.
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