Abstract
Purpose: Disconnected pancreatic duct syndrome (DPDS) is a complication of acute necrotizing pancreatitis in the neck and body of the pancreas often manifesting as persistent pancreatic fluid collection (PFC) or external pancreatic fistula (EPF). This systematic review and pairwise meta-analysis aim to review the definitions, clinical presentation, intervention, and outcomes for DPDS. Method: The PubMed, EMBASE, MEDLINE, and SCOPUS databases were systematically searched until February 2020 using the PRISMA framework. A meta-analysis was performed to assess the success rates of endoscopic and surgical interventions for the treatment of DPDS. Success of DPDS treatment was defined as long-term resolution of symptoms without recurrence of PFC, EPF, or pancreatic ascites. Results: Thirty studies were included in the quantitative analysis comprising 1355 patients. Acute pancreatitis was the most common etiology (95.3%, 936/982), followed by chronic pancreatitis (3.1%, 30/982). DPDS commonly presented with PFC (83.2%, 948/1140) and EPF (13.4%, 153/1140). There was significant heterogeneity in the definition of DPDS in the literature. Weighted success rate of endoscopic transmural drainage (90.6%, 95%-CI 81.0-95.6%) was significantly higher than transpapillary drainage (58.5%, 95%-CI 36.7-77.4). Pairwise meta-analysis showed comparable success rates between endoscopic and surgical intervention, which were 82% (weighted 95%-CI 68.6-90.5) and 87.4% (95%-CI 81.2-91.8), respectively (P=0.389). Conclusion: Endoscopic transmural drainage was superior to transpapillary drainage for the management of DPDS. Endoscopic and surgical interventions had comparable success rates. The significant variability in the definitions and treatment strategies for DPDS warrant standardisation for further research.
Highlights
Risk factors for clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD) are well established
All consecutive patients diagnosed with biochemical leak (BL) and CR-POPF after PD were identified from a prospective database (2009-2019)
DFA1 (p=0.006), DFA3 (p=0.006), DFA5 (p
Summary
TP08.05 EARLY POSTOPERATIVE DIFFERENTIATION BETWEEN BIOCHEMICAL LEAK AND CLINICALLY-RELEVANT POSTOPERATIVE PANCREATIC FISTULA AFTER PANCREATICODUODENECTOMY Introduction: Risk factors for clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD) are well established. The aim of this study was to identify early postoperative variables associated with CR-POPF. Methods: All consecutive patients diagnosed with BL and CR-POPF after PD were identified from a prospective database (2009-2019).
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