Abstract
Background Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz−Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS. Methods We conducted a single-center observational study, which included all patients diagnosed with PJS who underwent SBE for polypectomy between January 2018 and March 2021. Complete treatment was defined as the absence of polyps ≥10 mm after SBE resection. The clinical records were retrospectively reviewed. Results 102 patients (including 40 men and 62 women) with a mean age of 28.7 years (range 13–55 y) were enrolled in our study. The intubation depth via the oral approach of patients with a history of laparotomy was significantly shorter than that of the patients without a history of laparotomy ([241.6 ± 64.2] cm vs [280.9 ± 40.2] cm, P=0.008). The maximum size of the resected polyps via anus during the second hospitalization was significantly smaller than that during the first hospitalization ([2.25 ± 1.29] cm vs [4.26 ± 3.51] cm, P=0.032). For patients with total enteroscopy, the complete treatment rate was 98% (49/50). For patients without total enteroscopy, all polyps larger than 10 mm in the examined segment of small bowel were resected successfully. Complications occurred in 10 of 129 hospitalizations (delayed bleeding in 4, perforation in 3, and acute pancreatitis in 3). Conclusions SBE is effective and safe for resection of small bowel polyps in patients with PJS.
Highlights
Peutz−Jeghers syndrome (PJS) is a rare autosomal dominant hereditary disorder characterized by mucocutaneous melanin pigmentation and multiple gastrointestinal (GI) hamartomatous polyps [1]
Hamartomatous polyps can be detected in the small bowel, most commonly in the jejunum [2]. ese hamartomatous polyps in the small bowel can lead to bleeding, intussusception, and obstruction [3, 4]
Double-balloon enteroscopy (DBE) was first introduced by Yamamoto et al in 2001. e major advantage of DBE is that a wide variety of therapeutic interventions can be performed during the examination procedure [10,11,12]
Summary
Peutz−Jeghers syndrome (PJS) is a rare autosomal dominant hereditary disorder characterized by mucocutaneous melanin pigmentation and multiple gastrointestinal (GI) hamartomatous polyps [1]. Ese hamartomatous polyps in the small bowel can lead to bleeding, intussusception, and obstruction [3, 4]. DBE has been reported to be useful for the treatment of small bowel polyps in patients with PJS [13,14,15,16]. Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz−Jeghers syndrome (PJS). E aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS. For patients without total enteroscopy, all polyps larger than 10 mm in the examined segment of small bowel were resected successfully. SBE is effective and safe for resection of small bowel polyps in patients with PJS
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