Abstract

ABSTRACTBackground:Bariatric endoscopic techniques are minimally invasive and induce gastric volume reduction to treat obesity. Aim: To evaluate endoscopic sleeve gastroplasty (Apollo method) using a suturing method directed at the greater curvature, as well as the perioperative care, two year safety and weight loss. Method:Prospective single-center study over 154 patients (108 females) using the endoscopic sleeve gastroplasty procedure under general anesthesia with overnight inpatient observation. Of the154 initial patients, 143 were available for 1-month of follow-up, 133 for 6-month, 64 for 12-month and 28 completed the 24 month assessment. Follow-up was carried out by a multidisciplinary team (nutritionist and psychologist). Outcomes evaluated were: change in BMI; change in body weight (TBWL); % of loss of initial body weight (%TBWL); % of excess body weight loss (%EWL) (segregated in > or <25% and adverse effects. Voluntary oral contrasted radiological examinations were scheduled to assess the gastroplasty at different times post-procedure. Results:Mean age was 44.9 (23-69) years. At 24 months after the procedure baseline mean BMI change from 38.3 to 30.8 kg/m2. TBWL, %TBWL and %EWL were of 21.3 kg, 19.5% and 60.4% respectively. 85.7% of patients achieve the goal of >25% %EWL. There were no mayor adverse events intraprocedure or during the 24 months of follow-up. Conclusion:Endoscopic sleeve gastroplasty with regular monitoring by a multidisciplinary team can be considered an effective, safe and well tolerated procedure for obesity treatment, at least for two years of follow-up.

Highlights

  • Many obese cannot sustain sufficient weight loss to improve health with conventional medical lifestyle management[9]

  • Bariatric surgery is not indicated for some obesity grades

  • Less invasive endoscopic procedures are under development for the management of obesity; they provide a higher number of yet untreated obese patients with access to weight loss, allow earlier management, including childhood and juvenile obesity cases, and may be used in the obese elderly[1,2,4,5]

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Summary

Introduction

Many obese cannot sustain sufficient weight loss to improve health with conventional medical lifestyle management (diet, exercise and behavioral therapies)[9]. Long-lasting weight loss, and improves obesityrelated comorbidities in a relevant percentage of subjects. Obesity surgery is not exempt from risk, up to 90% of patients reject it, and it is often inaccessible (because of costs, location and lack of resources). Bariatric surgery is not indicated for some obesity grades. Only a small percentage of the obese population may access bariatric surgery[3]. Less invasive endoscopic procedures are under development for the management of obesity; they provide a higher number of yet untreated obese patients with access to weight loss, allow earlier management, including childhood and juvenile obesity cases, and may be used in the obese elderly[1,2,4,5]

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